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In such cases, clozaril has proven effective in relieving both positive and negative schizophrenic symptoms, with about one third of patients showing clinically relevant improvement.

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Consider reducing the clozaril dosage when discontinuing coadministered enzyme inducers; because discontinuation of inducers can result in increased clozapine plasma levels and an increased risk of adverse reactions see dosage and administration .

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Experience from clinical development, as well as from examples in the medical literature, suggest that patients who have developed agranulocytosis during clozaril clozapine therapy are at increased risk of subsequent episodes of agranulocytosis.

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